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Job #: G024
Posted Date: November 20, 2018
Closes On: Open Until Filled
Job Title: Research Assistant II - Molecular and Cell Biology Laboratory - Translational Research Team
Status: Regular Full Time
Benefits Eligible: Yes
Laboratory/Department: Molecular and Cell Biology Laboratory - Translational Research Team
Laboratory employs the help of a small DNA virus, called adenovirus, to both understand and treat cancer. A main focus of the translational research group in Dr. O’Shea’s laboratory is to use adenovirus as a platform for engineering potent virus-based therapeutics for the treatment of human cancer and other diseases. The translational group is responsible for all research activities from discovery through early pre-clinical development. These activities include the design and engineering of synthetic viruses (oncolytic viruses, viral vaccines, and vectors for delivery of virally-encoded therapeutics), in vitro and in vivo screening of virus candidates for safety and potency, and the initiation of pre-clinical development activities for lead candidate viruses in the pipeline.
Position Description:

The Research Assistant II is responsible for execution of in vivo cancer models to characterize novel virus-based therapies for cancer. The main focus of this position will be to perform human-mouse xenograft tumor models and syngeneic mouse models of cancer, and the candidate will be responsible for performing all techniques associated with the models including: Cell culture of human cancer cell lines using aseptic technique, inoculation of human tumor cell lines into immune deficient mice, monitoring of tumor growth by direct tumor measurements and in vivo imaging (IVIS) and subcutaneous, intravenous and intraperitoneal injections of therapeutic candidates.



  • BS degree in biological sciences.


  • MS degree in biological sciences.


  • Minimum of 3 years of relevant in vivo experience as a lab technician or research assistant.
  • Experience with tissue culture of primary cell lines and cancer cell lines.
  • Extensive experience with mouse handling, including routine husbandry, blood and tissue collection/sampling and routine injections (i.v., i.p., s.c.)


  • Experience with whole animal imaging (IVIS) strongly preferred.
Special Requirements:
  • Must be willing to work in an animal-related research environment.
  • Satisfactory completion of the Institute’s background investigation.
Physical Requirements:

This position requires constant adjusting focus, grasping, hearing, keying, seeing, sitting, analyzing, calculating, communicating, reading, reasoning, writing, working in confined areas and inside.

Application Instructions:

Please include a cover letter that responds to the following inquiries:

  • Please describe any relevant work experience as it pertains to this job description, including cell culture and in vivo mouse work?
  • Specifically, can you describe your experience performing mouse models of cancer?