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|Job #: G024|
|Posted Date: November 20, 2018|
|Closes On: Open Until Filled|
|Job Title: Research Assistant II - Molecular and Cell Biology Laboratory - Translational Research Team|
|Status: Regular Full Time|
|Benefits Eligible: Yes|
|Laboratory/Department: Molecular and Cell Biology Laboratory - Translational Research Team|
|Laboratory employs the help of a small DNA virus, called adenovirus, to both understand and treat cancer. A main focus of the translational research group in Dr. O’Shea’s laboratory is to use adenovirus as a platform for engineering potent virus-based therapeutics for the treatment of human cancer and other diseases. The translational group is responsible for all research activities from discovery through early pre-clinical development. These activities include the design and engineering of synthetic viruses (oncolytic viruses, viral vaccines, and vectors for delivery of virally-encoded therapeutics), in vitro and in vivo screening of virus candidates for safety and potency, and the initiation of pre-clinical development activities for lead candidate viruses in the pipeline.|
The Research Assistant II is responsible for execution of in vivo cancer models to characterize novel virus-based therapies for cancer. The main focus of this position will be to perform human-mouse xenograft tumor models and syngeneic mouse models of cancer, and the candidate will be responsible for performing all techniques associated with the models including: Cell culture of human cancer cell lines using aseptic technique, inoculation of human tumor cell lines into immune deficient mice, monitoring of tumor growth by direct tumor measurements and in vivo imaging (IVIS) and subcutaneous, intravenous and intraperitoneal injections of therapeutic candidates.
This position requires constant adjusting focus, grasping, hearing, keying, seeing, sitting, analyzing, calculating, communicating, reading, reasoning, writing, working in confined areas and inside.
Please include a cover letter that responds to the following inquiries: