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|Job #: F722|
|Posted Date: September 1, 2017|
|Closes On: Open Until Filled|
|Job Title: Research Assistant I - Laboratory of Genetics, Dr. Rusty Gage|
|Status: Regular Full Time|
|Benefits Eligible: Yes|
|Laboratory/Department: Laboratory of Genetics|
|Lab research concentrates on the adult central nervous system and unexpected plasticity and adaptability to environmental stimulation that remains throughout the life of all mammals.|
Under direct supervision, the position with execute experiments outlined by the Staff Research and PI. Duties will include transgenic mouse colony management and behavioral testing, molecular biology techniques and immunocyto chemistry.
The position will work on two projects in the Gage Lab.
This project will assist in experiments designed to understand memory function using a combination of behavioral analysis, immunohistochemistry and single-cell transcriptional profiling. We are investigating how gene expression changes in individual neurons of the hippocampal dentate gyrus when new memories are formed. Some experiments would involve substantial histological anlaysis of brain samples, include sectioning, staining, microscopy, and image analysis. Others may involve maintaining a colony of transgenic animals and rodent behavioral tests of hippocampus-dependent memory such as contextual fear conditioning. Finally, we are taking advantage of emerging single-cell sequencing technologies that require flow cytometry and library preparation for RNA-Seq.
This project focuses on the investigation of the molecular mechanisms underlying neuropsychiatric diseases in two aspects: first, study how germline mutations contribute to the development of Schizophrenia (SZ) using an induced pluripotent stem cell (iPSC) model from monozygotic twins that are discordant for SZ; second, investigate the molecular mechanism underlying mosaic copy number variations (CNVs) and its potential contribution to neuropsychiatric diseases. Molecular biology duties will include library prep, PCR, cloning and general nucleic acid manipulations.
This position requires constant seeing, adjusting focus, and working inside.