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|Job #: F259|
|Posted Date: July 5, 2016|
|Closes On: Open Until Filled|
|Job Title: Research Associate - Clayton Foundation Laboratories for Peptide Biology, Dr. Marc Montminy|
|Status: Regular Full Time|
|Benefits Eligible: Yes|
|Laboratory/Department: Clayton Foundation Laboratories for Peptide Biology|
|Current work in the lab focuses on the identification of CREB target genes and characterization of agonists and antagonists that may be used to evaluate the importance of CREB in mediating cellular responses to various stimuli.|
Our laboratory is focused on the mechanism by which hormonal signals trigger physiological changes in different organ systems by modulating key genetic programs. The second messenger cAMP mediates effects of a variety of extracellular cues on cellular gene expression via the PKA-mediated phosphorylation of CREB and via the de-phosphorylation of the CRTC family of CREB coactivators. We use biochemical and genetic approaches in both mice and Drosophila to characterize regulatory components of this pathway and to identify relevant target genes that contribute to the underlying physiology. We have generated mice with floxed alleles of CREB and CRTC family members to identify biological contexts in which this pathway is activated. Recent studies indicate that the CREB/CRTC pathway is critical in maintaining glucose homeostasis; it stimulates the hepatic expression of gluconeogenic genes in response to circulating glucagon during fasting; and it mediates effects of incretin hormones on insulin-producing beta cell viability in pancreatic islets under feeding conditions. Superimposed on it metabolic effects, the CREB/CRTC pathway also appears to mediate effects of prostaglandin E2 (PGE2) on innate and adaptive immunity. Future studies will focus on the potential role of metabolic signals in modulating the immune system through the activation of CREB. A long-standing interest of the lab is to characterize regulatory components of the CREB/CRTC pathway. Using mass spectrometry, we have identified a number of cofactors that modulate CREB target gene expression, apparently via epigenetic mechanisms. Future studies with these candidate cofactors will provide valuable insight into the mechanisms by which ubiquitous second messengers like cAMP exert distinct transcriptional effects in different tissues. Interested applicants with PhD or MD degree and interest in signaling, transcription, bioinformatics, or metabolic physiology are encouraged to send their CV.References:
|Application Instructions: Applicants should submit a current CV and names of three references to:
Marc R. Montminy, M.D., PhD