Part of the mission of the Salk Institute for Biological Studies is to train individuals for careers in scientific research. The expectation is that trainees will study in the many new fields developed by Institute faculty, learn the research techniques they have created, and go on to positions of leadership in other prominent scientific institutions. Postdoctoral training opportunities at the Institute are posted below.
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|Job #: E743|
|Posted Date: July 10, 2015|
|Closes On: Open Until Filled|
|Job Title: Research Associate - Molecular and Cell Biology Laboratory, Dr. Diana Hargreaves|
|Status: Regular Full Time|
|Benefits Eligible: Yes|
|Laboratory/Department: Molecular and Cell Biology Laboratory|
|Laboratory research focuses on understanding how chromatin structure contributes to normal development and oncogenic transformation. The lab studies the BAF ATP-dependent chromatin remodeling complex, an essential regulator of chromatin structure that is frequently mutated in human cancer, and seeks to understand the mechanistic basis of its tumor suppressor role.|
With continual advances in sequencing technologies, novel trends are being uncovered through the profiling of primary human tumors, illustrating the importance of epigenetic regulators and particularly subunits of the BAF ATP-dependent chromatin remodeling complex (Kadoch, Hargreaves et al. Nature Genetics 2013). We are currently seeking highly motivated postdoctoral fellows to functionally characterize loss-of-function mutations or deletions of BAF subunits using a combination of biochemical and next-generation sequencing methodologies. Our experiments are guided by identification of novel interacting proteins of BAF through proteomic mass spectrometry and genetic interaction mapping that point to new functions for the BAF complex and highlight nodes of therapeutic susceptibility. We hope to mechanistically define the pathways that permit and advance oncogenic transformation as a result of BAF subunit mutation and the therapeutic vulnerabilities that arise from this altered cellular state.
Candidates should have a Ph.D. or M.D. and experience in molecular and cellular biology.
Experience in biochemistry, basic molecular biology techniques (cloning, ChIP etc), RNAi screening, and next-generation sequencing methodologies is preferred.
Applicants should send curriculum vitae, statement of research interests and experience, and contact information for three references to: